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マウスにおける 2,5,2', 5'-Tetrachlorobiphenyl の代謝に及ぼすフェノバルビタールの影響(B. 生活科学)
https://kpu.repo.nii.ac.jp/records/5311
https://kpu.repo.nii.ac.jp/records/5311ae20cab8-1244-4ef9-9af5-04cf310008b7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000079437.pdf (434.3 kB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-02-20 | |||||
| タイトル | ||||||
| タイトル | マウスにおける 2,5,2', 5'-Tetrachlorobiphenyl の代謝に及ぼすフェノバルビタールの影響(B. 生活科学) | |||||
| 言語 | ja | |||||
| その他（別言語等） | ||||||
| その他のタイトル | Effects of Phenobarbital on the Metabolism of 2,5,2′, 5′-Tetrachlorobiphenyl in Mice (B. LIVING SCIENCE) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
水谷, 民雄
× 水谷, 民雄 |
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| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Effects of phenobarbital (PB), a potent inducer of microsomal drug-metabolizing enzymes, on the levels of metabolites of 2,5,2', 5'-tetrachlorobiphenyl (TCB) were studied in mice. Pretreatment of mice with PB (100mg/day/kg body weight) for 3 days before administration of a single dose of 2,5,2', 5'-TCB (8mg/mouse) resulted in 40 and 60% decreases of unchanged TCB in feces and whole-body tissues, respectively. The fecal extretion of methylthio-2,5,2', 5'-TCB's, which did not show any accumulation in tissues, was increased about 3 times the control value, whereas no alteration of the levels of methylsulfonyl-2,5,2', 5'-TCB's were observed in both feces and tissues. This marked increase in the level of methythio-TCB's is suggestive of the participation of microsomal drug-metabolizing enzymes in the formation of these metabolites. PB-pretreatment also resulted in a 40% increase in the fecal excretion of 3-hydroxy-2,5,2', 5'-TCB. | |||||
| 言語 | en | |||||
| 書誌情報 |
ja : 京都府立大学学術報告. 理学・生活科学 en : The scientific reports of the Kyoto Prefectural University. Natural science and living science 巻 28, p. 37-43, 発行日 1977-11-30 |
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| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00062300 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0075739X | |||||
